Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negative regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed

Regulator ID	Locus tag (Gene)	Related T6SS	Regulator type	Regulatory pathway	Organism	Replicon (Accession)	Coordinates (Strand)	NCBI ID	Target (Regulation)
REG0220	ETAE_2787 (guaB)	T6SS00372	protein	TCS regulatory pathway	Edwardsiella tarda EIB202	chromosome (NC_013508)	2925310..2926776 (-)	502612646	ETAE_0886 (esrB) promoter (↑)
REG0096	PSPTO_RS08845 (relA)	T6SS00041 ; T6SS00042	protein	(p)ppGpp regulatory pathway	Pseudomonas syringae pv. tomato str. DC3000	chromosome (NC_004578)	1863879..1866122 (+)	494457621	T6SS transcripts (↓)
REG0148	PSYR_RS19090 (relA)	T6SS00086	protein	(p)ppGpp regulatory pathway	Pseudomonas syringae pv. syringae B728a	chromosome (NC_007005)	4380642..4382885 (-)	499587809	T6SS transcripts (↓)
REG0187	YPK_3449 (RelA)	T6SS00260	protein	(p)ppGpp regulatory pathway	Yersinia pseudotuberculosis YPIII	chromosome (NC_010465)	3783755..3785989 (-)	488138165	YPK_1551 (RovM) (↓); YPK_1876 (RovA) (↓)
REG0097	PSPTO_RS00410 (spoT)	T6SS00041 ; T6SS00042	protein	(p)ppGpp regulatory pathway	Pseudomonas syringae pv. tomato str. DC3000	chromosome (NC_004578)	94805..96910 (-)	492171753	T6SS transcripts (↓)
REG0149	PSYR_RS01070 (spoT)	T6SS00086	protein	(p)ppGpp regulatory pathway	Pseudomonas syringae pv. syringae B728a	chromosome (NC_007005)	223004..225109 (-)	489499092	T6SS transcripts (↓)
REG0218	ETAE_0358 (purA)	T6SS00372	protein	TCS regulatory pathway	Edwardsiella tarda EIB202	chromosome (NC_013508)	403538..404836 (+)	502610221	ETAE_0886 (esrB) promoter (↑)
REG0302	VCA1552_RS12925 (cya)	T6SS01112	protein	QS regulatory pathway; cAMP regulatory pathway	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	2747346..2749877 (-)	447072406	VCA1552_RS12025 (crp) (↓)
REG0098	PSPTO_RS04545 (fpRel)	T6SS00041 ; T6SS00042	protein	(p)ppGpp regulatory pathway	Pseudomonas syringae pv. tomato str. DC3000	chromosome (NC_004578)	927082..927900 (+)	499415849	T6SS transcripts (↓)